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  • Seismic reflection mapping, geochemical analyses and petroleum systems modelling have increased our understanding of the highly prospective Mesoproterozoic and Paleoproterozoic source rocks across northern Australia, expanding the repertoire of exploration targets currently being exploited in Proterozoic petroleum systems. Data collected during the Exploring for the Future program have enabled us to redefine and increase the extent of regional petroleum systems, which will encourage additional interest and exploration activity in frontier regions. Here, we present a review of the Paleoproterozoic McArthur and Mesoproterozoic Urapungan petroleum supersystems, and the most up-to-date interpretation of burial and thermal history modelling in the greater McArthur Basin (including the Beetaloo Sub-basin), South Nicholson Basin and Isa Superbasin. We also present potential direct hydrocarbon indicators imaged in the 2017 South Nicholson Deep Crustal Seismic Survey that increase the attractiveness of this frontier region for hydrocarbon exploration activities. <b>Citation:</b> MacFarlane, S.K., Jarrett, A.J.M., Hall, L.S., Edwards, D., Palu, T.J., Close, D., Troup, A. and Henson, P., 2020. A regional perspective of the Paleo- and Mesoproterozoic petroleum systems of northern Australia. In: Czarnota, K., Roach, I., Abbott, S., Haynes, M., Kositcin, N., Ray, A. and Slatter, E. (eds.) Exploring for the Future: Extended Abstracts, Geoscience Australia, Canberra, 1–4.